Chris Bohjalian is the son of Aram Bohjalian, who was a senior vice president of the New York advertising agency Romann & Tannenholz. Chris Bohjalian graduated summa cum laude from Amherst College, where he was a member of the Phi Beta Kappa Society. In the mid-1980s, he worked as an account representative for J. Walter Thompson advertising agency in New York.

Chris Bohjalian and his wife lived in a co-op in Brooklyn until March 1986, when the two were riding in a taxicab in which the driver refused to let them out of the car for 45 minutes, ignoring all traffic lights and stop signs. Around midnight, the driver dropped them off at a near-deserted street in front of a crack house, where the police were conducting a raid and Bohjalian and his wife were forced to drop to the ground for their protection. The incident prompted the couple to move from Brooklyn; Bohjalian said, "After it was all over, we just thought, 'Why do we live here?'" A few days later, the couple read an ad in The New York Times referencing the "People's Republic of Vermont", and the couple decided to move to Lincoln.

They bought a house in Lincoln in 1987.

Bohjalian began writing weekly columns for local newspaper and magazine about living in the small town, which had a population of about 975 residents. The ''[[Concord Monitor]]'' said of Bohjalian during this period, "his immersion in community life and family, Vermont-style, has allowed him to develop into a novelist with an ear and empathy for the common man." Bohjalian continued the column for about 12 years, writing about such topics as his own daily life, fatherhood and the transformation of America. The column has run in the [[Burlington Free Press]] since 1992. Bohjalian has also written for such magazines as ''[[Cosmopolitan (magazine)|Cosmopolitan]]'', ''[[Reader's Digest]]'' and the ''[[The Boston Globe|Boston Globe Sunday Magazine]]''.

Bohjalian's first novel, A Killing in the Real World, was released in 1988. Almost two decades after it was released, Bohjalian said of the book, "It was a train wreck. I hadn't figured things out yet." His third novel, Past the Bleachers, was released in 1992 and was adapted to a Hallmark Channel television movie in 1995.

In 1998, Bohjalian wrote his fifth book, Midwives, a novel focusing on rural Vermont midwife Sibyl Danforth, who becomes embroiled in a legal battle after one of her patients died following an emergency Caesarean section. The novel was selected by Oprah Winfrey as the October 1998 selection of her Oprah's Book Club, which helped push the book to great financial success. It became a New York Times and USA Today bestsellers. Victoria Bohjalian has often described her husband as having "a crush" on the Sybil Danforth character. In 2001, the novel was adapted into a Lifetime Movie Network television film starring Sissy Spacek in the lead role. Spacek said the Danforth character appealed to her because "the heart of the story is my character's inner struggle with self-doubt, the solo road you travel when you have a secret".

Bohjalian followed Midwives with the 1999 novel The Law of Similars, about a widower attorney suffering from nameless anxieties who starts dating a woman who practices alternative medicine. The novel was inspired by Bohjalian's real-life visit to a homeopath in an attempt to cure frequent colds he was catching from his daughter's day care center. Bohjalian said of the visit, "I don't think I imagined there was a novel in homeopathy, however, until I met the homeopath and she explained to me the protocols of healing. There was a poetry to the language that a patient doesn't hear when visiting a conventional doctor." The protagonist, a father, is based in part on Bohjalian himself, and his four-year-old daughter is based largely on Bohjalian's daughter, who was three when he was writing the book. Liz Rosenberg of The New York Times said the novel shared many similarities with Midwives but that it paled in comparison; Rosenberg said, "Unlike its predecessor, it fails to take advantage of Bohjalian's great gift for creating thoughtful fiction featuring characters in whom the reader sustains a lively interest." Megan Harlan of The Boston Phoenix described it as "formulaic fiction" and said Bohjalian focused too much on creating a complex plot and not enough of complex characterizations. The Law of Similars, like Midwives, made the New York Times bestsellers list.

He won the New England Book Award in 2002. "The Double Bind" was a Barnes & Noble Recommends Selection in 2007.

In 2007, Bohjalian released Skeletons at the Feast, a love story set in the last six months of World War II in Poland and Germany. The novel was inspired by an unpublished diary written by German citizen Eva Henatsch from 1920 to 1945. The diary was given to Bohjalian in 1998 by Henatsch's grandson Gerd Krahn, a friend of Bohjalian, who had a daughter in the same kindergarten class as Bohjalian's daughter. Bohjalian was particularly fascinated by Henatsch's account of her family's trek west ahead of the Soviet Army, but he was not inspired to write a novel from it until 2006, when he read Armageddon: The Battle for Germany, Max Hastings' history of the final years of World War II. Bohjalian was struck not only by how often Henatsch's story mirrored real-life experiences, but also the common "moments of idiosyncratic human connection" found in both. Skeletons of the Feast was considered a departure for Bohjalian because it was not only set outside of Vermont, but set in a particular historical moment.

In an interview with www.bn.com he said:

"I was the heaviest child, by far, in my second-grade class. My mother had to buy my pants for me at a store called the "Husky Boys Shop," and still she had to hem the cuffs up around my knees. I hope this experience, traumatizing as it was, made me at least marginally more sensitive to people around me."

"I have a friend with Down syndrome, a teenage boy who is capable of remembering the librettos from entire musicals the first or second time he hears them. The two of us belt them out together whenever we're driving anywhere in a car.

"I am a pretty avid bicyclist. The other day I was biking alone on a thin path in the woods near Franconia Notch, New Hampshire, and suddenly before me I saw three bears. At first I saw only two, and initially I thought they were cats. Then I thought they were dogs. Finally, just as I was approaching them and they started to scurry off the path and into the thick brush, I understood they were bears. Bear cubs, to be precise. Which is exactly when their mother, no more than five or six feet to my left, reared up on her hind legs, her very furry paws and very sharp claws raised above her head in a gesture that an optimist might consider a wave and guy on a bike might consider something a tad more threatening. Because she was standing on a slight incline, I was eye level with her stomach...an eventual destination that seemed frighteningly plausible. I have never biked so fast in my life in the woods. I may never have biked so fast in my life on a paved road."

"I do have hobbies -- I garden and bike, for example -- but there's nothing in the world that gives me even a fraction of the pleasure that I derive from hanging around with my wife and daughter."

He lives with his wife and daughter in Lincoln, Vermont, where he is active in the local church and the Vermont theater community...always off-stage, never on.

Bohjalian novels often focus on a specific issue, such as homelessness, animal rights and environmentalism, and tend to be character-driven, revolving around complex and flawed protagonists and secondary characters. Bohjalian uses characteristics from his real life in his writings; in particular, many of his novels take place in fictional Vermont towns, and the names of real New Hampshire towns are often used throughout his stories. Bohjalian said, "Writers can talk with agonizing hubris about finding their voices, but for me, it was in Vermont that I discovered issues, things that matter to me." His novels also tend to center around ordinary people facing extraordinarily difficult situations resulting from unforeseen circumstances, often triggered by other parties.

On October 13, 1984, Bohjalian married Victoria Schaeffer Blewer during a ceremony at the Brick Presbyterian Church in New York City; his brother, Andrew Peter Bohjalian, served as his best man. Chris and Victoria currently live in Lincoln, Vermont, with their daughter, Grace.