Seeley has illustrated a variety of comics, including Kore, G.I. Joe, G.I. vs. Transformers, and The Dark Elf Trilogy.

He is also the author of the comic HACK/slash series, and will participate in the Hack/Slash film. It is due to be released by Universal Pictures in 2009.

His most recent endeavor, Loaded Bible (published by Image Comics), gained a great deal of attention for its political-action theme of Jesus vs. Vampires in a post-apocalyptic Christian-run society.

Seeley has been hired by Marvel Comics to pencil New Exiles, and Weapon X: First Class.

Seeleys webcomic Colt Noble and the Megalords debuted on Nerd City Online on August 3, 2009. He write currently on the Werewolf comic Wild Game, which based on the Underworld and An American Werewolf in London.