Becker is best known for her 1990 internationally bestselling book All I Need to Know I Learned from My Cat. All I Need to Know I Learned from My Cat sold two million copies and spent 28 weeks on the New York Times bestseller list, with several weeks at #1.

Becker graduated from Brown University in 1984 with bachelor’s degrees in economics and international relations, and spent her first summer out of college biking 4500 miles across the United States. After a brief period as a second grade teacher at the American School of Barcelona, she moved to Boston, Massachusetts to start her writing career.

Becker began as an advertising copywriter in Boston. The job allowed her to hone her talents for insightful and irreverent writing, which would later become her trademark in her books and cartoons. In 1987, she founded her greeting card company, the Widget Factory, which garnered recognition for its humor, witty drawings, and corporate social responsibility. From 1987 until 1993, Becker worked as president, and owner of the Widget Factory greeting card line, creating over 200 different card designs, posters, and a maternity Advent calendar (which she invented).

Additionally, during that time, Becker also spearheaded national service projects, including, Ride FAR, the first U.S. HIV/AIDS bike-a-thon. Ride FAR, or the Ride for AIDS Resources, is a biannual event that gives 100% all proceeds raised directly to services for children and adults living with HIV/AIDS. To date, the ride has raised more than $1,100,000 for HIV/AIDS resources.

Becker eventually licensed the Widget Factory in early 1993, so that she could accept her appointment as a White House Fellow under President Bill Clinton from 1993-1994. Upon her return from her fellowship at the White House, Becker helped found and taught at the Francis W. Parker Charter Essential School, an alternative public secondary school in central Massachusetts. She left the school after a few years to focus on writing and illustrating full time.

Becker’s books include All I Need to Know I Learned from My Cat now in the "Double-Platinum Collector's Edition All I Need to Know I Learned from My Cat (and Then Some), My Dog’s the World’s Best Dog, Manny’s Cows: The Niagara Falls Tale, an illustrated memoir about her own struggle and recovery from brain surgery entitled: I Had Brain Surgery, What’s Your Excuse?, and a board book with teething corners for babies entitled Books Are for Reading.

Her most recent book Kids Make It Better is a write-in, draw-in world problem-solving journal for 6 -10 year olds. The book also features sidebar profiles of kids under the age of 10 who have made a difference, observation logs and a "Make It Better" Action Plan.

Becker's work has appeared in various publications including Mademoiselle, Funny Times, The Best Contemporary Women’s Humor, Grist.org, SEED, and The Boston Globe. Additionally, her work has been commissioned by the National Audubon Society, American Museum of Natural History, National Geographic Society, and the Environmental Defense Fund. It has also been exhibited in solo and group shows throughout New England and New York, and is part of the permanent collection at the Museum of Comic and Cartoon Art. She illustrated the comic strip Rhymes With Orange while its creator Hilary Price was on vacation, June 9-14 and 22, 2008.

Becker currently lives in Bolton, Massachusetts with her daughter and life partner, along with their dog and two formerly feral cats.