Benecke was born in Germany in 1970. After receiving a Dr. rer. medic. at Cologne University in 1997, he worked in the Chief Medical Examiner's Office in Manhattan, New York from 1997—1999. As of 2008, he works internationally on forensic cases as a freelance expert witness. He also teaches at various police academies and acts as a visiting professor to universities in Germany, England, Vietnam, Colombia, and the Philippines.
Benecke has worked on the identification of Adolf and Eva Hitler's skull and teeth in Moscow, and is the only forensic scientist to work with Columbian serial killer and rapist Luis Garavito. Some of his forensic cases have been covered by the National Geographic Channel and the History Channel.
Benecke has published several popular science books about the biology of aging, criminal cases and forensic biology. He is a member of the editorial board of the Annals of Improbable Research (Cambridge, USA), guest editor for Forensic Science International (Forensic Entomology Special Issue), and scientific advisor to the German skeptic organization GWUP, where he publishes skeptical articles on various topics, including his attempt to explain alleged signs of vampirism.
Using the pseudonym "Belcanto Bene", Benecke was a member of the German punk band Die Blonden Burschen between 1989—2000.
In 2010, he was candidate for the office of prime minister for Germany's largest state North Rhine-Westphalia for the political party Die Partei.
Dem Täter auf der Spur. So arbeitet die moderne Kriminalbiologie, Lübbe, Bergisch-Gladbach 2006. ISBN 3-404-60562-4 (German)
Mordspuren. Neue spektakuläre Kriminalfälle — erzählt vom bekanntesten Kriminalbiologen der Welt, Lübbe, Bergisch Gladbach 2007 ISBN 978-3-7857-2307-4 (German)
Medical Detectives, vgs Verlagsgesellschaft, Köln 2005. ISBN 3-8025-3446-8 (German)
Vampires among us, Sequenz Medien Produktion, Fuchstal-Welden 2006. ISBN 3-935977-75-1
Wo bleibt die Maus?, Sauerländer, Oberentfelden 2008. ISBN 3-7941-5174-7 (German)
Hvor blev musen af? En historie om livets kredsløb, Klematis Forlag. ISBN 87-641-0304-8 (Danish, Oversætter: Mette Jørgensen, Illustrationer: Lisa Fuss)
Ölümün ?zleri, K?rm?z? Kedi. ISBN 978-9944-75-619-8 (Turkish)
Warum man Spaghetti nicht durch zwei teilen kann, Luebbe, Bergisch Gladbach 2009. ISBN 3-7857-2368-7
Vampire unter uns! (mit E. Wawrzyniak, N. Palanetskaya & K. Sonntag), Edition Roter Drache, Rudolstadt, 2009. ISBN 978-3-939459-24-8
?? ??? ??? ??? / ??????? ???? ???? ???, ??? (Dem Ta). ISBN 978-89-92525-33-6 (Korean Version of "Dem Täter auf der Spur")
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