Moreland is a prolific Christian author, lecturer, and debater on a wide range of philosophical, religious, and social issues. He is best known for his contributions to contemporary philosophical apologetics, his critiques of materialism and naturalism, and his defense of Christian theism. He has published works in the fields of philosophy of mind, action theory, philosophy of science, ethics, theology, metaphysics and philosophy of religion. Moreland also serves as fellow of the Discovery Institute's Center for Science and Culture which is considered the hub of the intelligent design movement. Moreland has also contributed to several books by Lee Strobel, including The Case for a Creator.

Moreland has authored or co-authored numerous publications, including:

• Scaling the Secular City: A Defense of Christianity (1987)
• Christianity and the Nature of Science: A Philosophical Examination (1989)
• The Life and Death Debate: Moral Issues of Our Time (with Norman Geisler, 1990)
• Does God Exist?: The Debate Between Atheists and Theists (with Kai Nielsen, 1990)
• The Creation Hypothesis: Scientific Evidence for An Intelligent Designer (1994)
• Love Your God With All Your Mind: The Role of Reason in the Life of the Soul (1997)
• Body and Soul: Human Nature and the Crisis of Ethics (with Scott Rae, 2000)
• Naturalism: A Critical Analysis (co-editor with William Lane Craig, 2000)
• Philosophical Foundations for a Christian Worldview (with William Lane Craig, 2003)
• Kingdom Triangle: Recover the Christian Mind, Renovate the Soul, Restore the Spirit's Power (2007)
• Consciousness and the Existence of God (2009)
• The Recalcitrant Imago Dei (2009)
• The God Question: An Invitation to a Life of Meaning (2009)