Roman is the co-creator of Jax Epoch and the Quicken Forbidden (AiT/Planet Lar), a Harvey Award-nominated webcomic. He also co-created Teen Boat (Cryptic Press), an Ignatz Award-winning webcomic. Both were with artist John Green.

He has contributed to comics anthologies including Flight 3, Not My Small Diary, and Bizarro World for DC Comics. Astronaut Elementary is his weekly webcomic which was awarded a Web Cartoonists' Choice Award for in 2005. In October 2006 his comic Agnes Quill was published by Slave Labor Graphics and in 2008 it was optioned by Paramount Pictures. He has also designed a CD cover for the wizard rock band Harry and the Potters.

Roman is married to Raina Telgemeier (artist of graphic novel adaptations of The Baby-sitters Club series). He is currently an Associate Editor for Nickelodeon Magazine.