Peyer started drawing political cartoons and illustrations for various student underground newspapers in his hometown of Syracuse, New York, while in high school. His professional career began as a newspaper cartoonist for The Syracuse New Times, an alternative weekly newspaper in Syracuse, New York. In this role, he came to the attention of Roger Stern, a Syracuse resident.

Peyer was an editor at DC Comics/Vertigo during the same time as Mark Waid, and the two have been frequent collaborators. Another long-time collaborator is writer Hart Seely, with whom Peyer created a collection of found poetry based on the calls of baseball icon Phil Rizzuto.

Comics

As writer

• Action Comics, #638, 640, 641, 723, 757
• Adventure Comics, 80-Page Giant (1998)
• Adventures of Superman, 2008 Annual, #536, 570
• "All-Star Comics 80-Page Giant" (1999)
• Amazing Spider-Man Digital (2009) #13-15
• Amazing Spider-Man Family (2008), #8
• The Amazing Spider-Man #623, 624, 628

Spider-Man: The Gauntlet, vol. 03

• Atom Special (1993) #1 and 2
• The Authority (1999)#23-26 ("Transfer of Power")
• Gotham Knights (2000) #15 ("Far From the Tree")
• Legends of the Dark Knight #169-171 ("Irresistable", Parts One, Two, and Three)
• Big Book of... #6 ("Big Book of Little Criminals") and 7 ("Big Book of Hoaxes")
• Bongo Comics Free-For-All (2006)
• Bongo Comics Presents Simpsons Super Spectacular (2006), #4
• Cruel and Unusual (with co-author Jamie Delano, pencils by John McCrea and inks by Andrew Chiu, Vertigo, 4-issue mini-series, 1999)
• Cthulhu Tales (2008), #1
• DC 2000 (2000), #1 and 2
• Doctor Fate (1988), #35 and 36
• Doom 2099 (1993), #41
• Elseworlds 80 Page Giant (1999), #1
• Flash & Green Lantern: The Brave and the Bold (1999), #1-6
• The Flash 80-Page Giant (1998), #2
• The Flash Secret Files (1997), #2
• The Flash (1987) Annual 8, #238-243
• Go Boy 7: Human Action Machine (2003), #1-4
• Golden Age Secret Files (2001), #1
• Hourman #1-25
• House of M (2005)
• House of M: Spider-Man, Fantastic Four & X-Men (2009)
• Impulse (1995), Annual 02, #19 and 28
• JLA 80-Page Giant (1998), #1 and 2
• JLA in Crisis Secret Files and Origins (1998), #1
• JLA Secret Files and Origins (1997), 33
• JLA: Tomorrow Woman (1998), #1
• Justice Leagues Part I: Twighlight's Last Gleaming
• Justice Leagues Part VI: Dawn's Early Light
• The Justice Society Returns
• L.E.G.I.O.N. (1989), Annual 05, #61-70
• Legends of the DC Universe 80-Page Giant (1998), #2
• Legends of the Legion (1998), #1-4
• Legion of Super-Heroes (1989), Annual 06 and 07, #65-121, #1000000
• Legion of Super-Heroes: The Beginning of Tomorrow (1999)
• Legion: Secret Files (1998), #1 and 2
• Legionnaires (1993), #19-34, 36, 40, 44, 47, 54, 75, 1000000
• Magnetic Men Featuring Magneto (1997), #1
• Magnus Robot Fighter (1997), #1-18
• The Making of Hourman (1998), #1
• Marvel Apes (2008), #1 and 2
• Marvel Apes: Amazing Spider-Monkey Special (2009), #1
• Marvel Apes: Grunt Line Special (2009), #1
• Marvel Apes: Speedball Special (2009), #1
• Marvel Apes: The Evolution Starts Here (2009)
• Marvel Team-Up (1997), #1-6, 8-11
• Marvel Valentine Special (1997), #1
• New Gods (vol. 4) #1-11 (with co-author Rachel Pollack, and pencils by Luke Ross, DC Comics, 1995—1996)
• Noble Causes: Extended Family (2003), #2
• Power of the Atom (1988), #14-18
• The Pulse: House of M Special (2005), #1
• The Punisher (2001), #9-12
• Quicksilver (1997), #1-6
• R.E.B.E.L.S. '94 (1994), #0-2
• R.E.B.E.L.S. '95 (1995), #3-14
• R.E.B.E.L.S. '96 (1996), #15-17
• Return to the Amalgam Age of Comics (1997)

Volume 2 - "The Marvel Comics Collection"

• Rocket Comics: Ignite (2003), #1
• Secret Origins 80-Page Giant (1998), #1
• Secret Origins of Super Villains (1999), #1
• Showcase '96 (1996), #11 and 12
• Silver Age: Doom Patrol (2000), #1
• Simpsons Comics (1993), #125
• Simpsons Comics Presents Bart Simpson (2000), #21-23, 25, 26, 28-30, 34, 42
• Simpsons Comics Presents Bart Simpson vol. 06, "Big Beastly Book of Bart Simpson"
• Smash Comics (1999), #1
• Solar, Man of the Atom: Hell on Earth (1998), #2
• Spider-Man Team-Up (1995), #1
• Spider-Man: House of M (2005), #1-5
• Stephen Colbert's Tek Jansen (2007), #1-5
• Superboy (1990), #14
• Supergirl (1996), Annual 02
• Superman (1987), #31, #114
• Superman & Batman Magazine (1993), #3
• Superman Plus (1997), #1
• Superman: The Man of Steel (1991), #58, 92
• Team Titans (1992), #11 and 12
• The Titans (1999), #42-50
• Totems (with Richard Case, Duncan Fegredo and Dean Ormston, Vertigo, 2000)
• Web of Spider-Man (2009), #2
• Wha...Huh? (2005), #1
• Wildstorm Winter Special (2005)
• Wonder Woman (1987), #63
• X-Nation 2099 (1996), #1-3
• ZERO (1974), #2
• Zombie Tales: The Series (2008), #9

As editor

• Animal Man (1988), Annual 1, #35-63.
• Black Orchid (1988), Annual 1, #1-4
• Constantine: The Hellblazer Collection (2005)
• Doom Force Special (1992), #1 ("Judgment Day")
• Doom Patrol (1987), Annual 02, #44-71
• Hellblazer (1988), #29-41
• Kid Eternity (1993), #1-8
• The Sandman (1989), #16-25
• Shade, the Changing Man (1990), #1-12
• Swamp Thing, #96-100
• Vertigo Jam (1993), #1
• Vertigo Visions: The Geek, #1
• Vertigo Visions: Phantom Stranger, #1
• War of the Gods (1991), #2-4
• Who's Who in the DC Universe, #9, 10, 15
• Wonder Woman (1987), #43-62

Books

Interviews

• Interview with Tom Peyer, “Tek Jansen” comic author, No Fact Zone, February 16, 2007
• Interview: Tom Peyer on 'The Flash' and 'Tek Jansen', March 8, 2008
• Tom Peyer: Time Is On His Side, Comics Bulletin
• Interview with Tom Peyer, comics author (audio), War Rocket Ajax, October 18, 2009

Tom Peyer