Pugh's earliest work included penciling John Ostrander's Youngblood, telling the story of his futuristic sword and sorcery character Grimjack's childhood and early adulthood, as well as providing covers for the Grimjack Case Files limited series. He also illustrated Pat Mills' Third World War before starting a brief run on Hellblazer with writer Jamie Delano.

Recent work includes writing and drawing Hotwire: Requiem for the Dead, a story based on concepts developed by Warren Ellis. It was originally planned to appear in Atomeka Press's Blast and then in 2005 their Bojeffries Terror Tomes #1 before finally being published by Radical Comics.

Comics work includes:

• Third World War (with Pat Mills):
• "Ivan's story: Why me?" (in Crisis, #36, January 1990)
• "Anchorman" (in Crisis, #50, September 1990)

• Youngblood (back-up story in Grimjack #70-81, May 1990 - April 1991)
• Hellblazer #32—33, 37—39 (with Jamie Delano, Vertigo, August 1990 - March 1991)
• Strontium Dog: "Monsters" (with Garth Ennis, in 2000 AD #750-761, September—December 1991)
• Animal Man (with Jamie Delano, DC, #51-79, 1992—1994)
• Saint of Killers #1-2, 4 (with Garth Ennis, 4-issue mini-series, Vertigo, 1996)

• Penthouse Comix:
• "Velvet Flytrap & Friends" (pin-up, in Penthouse Comix #10, 1995)
• "Young Captain Adventure: Mars Needs Men!!!" (with Ian Edginton, in Penthouse Comix #13, 1996)
• "By Royal Appointment: The Queen of England" (illustrated text story, with unknown author, in Penthouse Comix #29, 1998)
• "Rolling Thunder: Big Girls Don't Cry" (with Ian Edginton, in Penthouse Comix #31, 1998)

• 2020 Visions (with Jamie Delano, Vertigo, 12 issue mini-series #10-12, 1997)
• Hitman (with writer Garth Ennis and co-artist Carlos Ezquerra, Pulp Heroes Annual #1, DC Comics, 1997)
• Dead Corps (with writer Christopher Hinz), Helix / DC Comics, 4 issue mini-series, 1998
• Darkseid (with Jamie Delano, DC, 2 part mini-series, 2000)
• Death to the Future (pencils, with writer Alan Grant and inks by Mike Perkins, 4-issue mini-series, DC Comics and Dark Horse comics, 2000)
• Generation X (with co-writers Warren Ellis & Brian Wood and inker Sandu Florea, Marvel, 2000—2001)
• Blade #1-5 (with writer Christopher Hinz, Marvel MAX, May—September 2002)
• Interceptor (with Ian Edginton, in 2000 AD #1337-1345, 2003)
• Vampirella/Witchblade #1: "Brooklyn Bounce" (with Brian Wood, Harris Comics, 2003)
• Judge Dredd: "Inside Job" (with Ian Edginton, in 2000 AD #1363-1364, 2003)
• "Honor Bound" (with Ian Edginton, in Star Wars Tales 22, 2005)
• Rogue Trooper: "New Model Army" (with Ian Edginton, in 2000 AD #1477-1479, 2006)
• Nevermore: "The Pit and the Pendulum" (with Jamie Delano, graphic novel adaptation, Eye Classics, Self Made Hero, October 2007, ISBN 978-0-9552856-8-4)
• Hotwire: Requiem for the Dead (script and art, Radical Comics, forthcoming