Search - Signal Transduction: A Practical Approach (Practical Approach Series)

Signal Transduction A Practical Approach - Practical Approach Series

Cellular trans-membrane signalling mechanisms are among the most highly studied processes in the biological sciences. G-proteins provide transduction components to allow communication between receptors for hormones and neurotransmitters and their effector systems which include enzymes involved — in the generation of intracellular secondary messen...  more »gers and a variety of ion channels. Signal Transduction: A Practical Approach details the experimental approaches which are used to define the contacts between receptors and G-proteins and between these G-proteins and their effector systems. While

much emphasis in the cellular signalling field remains on the measurement of adenylyl cyclase and of phosphoinositidase C activities, it is now clear that activation of G-protein linked receptors can also cause the regulation of phospholipases of the D and A2 classes. Thus, assays used to measure

the activities of these enzyme systems are detailed in this book. The use of mutagenesis to define functional domains of G-proteins themselves has undergone considerable progress recently and examples of this approach are also included. This volume provides a useful guide to the newcomer to the

subject, as well as allowing workers already in the field to expand the range of approaches in use in their laboratories.  « less

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ISBN-13: 9780199632954
ISBN-10: 0199632952
Publication Date: 9/24/1992
Pages: 208
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Publisher: Oxford University Press, USA
Book Type: Paperback
Members Wishing: 0
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