Moss began his career as science writer at Memorial Sloan-Kettering Cancer Center in 1974. His responsibilities included writing monthly articles for the in-house publication, Center News. While at Sloan-Kettering, Moss befriended Kanematsu Sugiura, a senior scientist who claimed to have observed positive effects in mice with the controversial compound amygdalin (sometimes called "laetrile"). Moss claimed that Sugiura's positive results were being suppressed and that he was being asked to issue false statements about the testing. In regard to this situation, he wrote:
My options at that point were very few. I could have just quit and gone off quietly. But what about all the people who had cancer who were calling every day, and the 500,000 people who are dying every year of cancer in the U.S. alone? So I kept on pursuing the truth of this matter, and it kept on getting worse and worse. Ultimately, I called a press conference to issue a counter report to the Sloan-Kettering report on laetrile. The result of course was that I was fired for "failing to carry out my most basic job responsibilities". So my most basic job responsibilities, I guess, was to lie on behalf of Memorial Sloan-Kettering. I couldn't do that and I didn't do that.
Moss subsequently pursued a career as an independent science journalist. In 1980, he wrote his first book
The Cancer Syndrome, which was subsequently reissued as
The Cancer Industry. In the same year he co-authored
An Alternative Approach to Allergies with Theron G. Randolph. In the 1980s he wrote
A Real Choice, which was about breast-sparing conservative surgery, and
Free Radical, a biography of the Nobel laureate Albert Szent-Gyorgyi. He subsequently wrote
Cancer Therapy,
Herbs Against Cancer and
Antioxidants Against Cancer. He also coedited the American edition of
Complementary Oncology, with the German oncologist Josef Beuth.
In 1994, Moss co-founded Cancer Communications, Inc., a company which provides independent assessments of various cancer treatments, both conventional and unconventional. Moss has written over 200 diagnosis-specific reports for the company, which is located in Lemont, Pennsylvania. Since 2001, he has written "Cancer Decisions", an online weekly newsletter. Moss has visited cancer clinics in the Bahamas, China, Honduras, Italy, Mexico, and Germany, and is an honorary member of the German Oncology Society.