Kindt was born in St. Louis and currently resides in Webster Groves, Missouri. He worked in the local mini-comics scene from a young age, self-publishing his own copyshop zines since 1990. In 1995 he obtained a Graphic Design degree from Webster University in St. Louis.

In 2001, Top Shelf Productions published his first full graphic novel, Pistolwhip. The book was critically well-received, nominated for the prestigious Harvey Award the next year and featured in Time Magazine's Top 10 list for Graphic Novels, yet remained in relative obscurity. To this day he has continued to be extremely prolific, however, and has illustrated two Pistolwhip spin-offs (Mephisto and the Empty Box and Pistolwhip 2) and written his own, 300-page graphic novel, Two Sisters, as well as maintaining a regular webcomic set in the Sisters universe, called Super Spy. In 2006, Kindt announced on his blog that he would be writing an experimental novel called The End of the World, though it is unknown whether the book is still planned. In 2007, the collected Super Spy was published by Top Shelf. 2008 saw the collected Super Spy nominated for the Eisner Award for Best Graphic Novel: Reprint. March 2010 saw a Super Spy short story appeared on Dark Horse's Dark Horse Presents MySpace web comic. Kindt has a new title out in 2010, called Revolver, publisher by DC Comics' Vertigo imprint.

Kindt's work is frequently set in the world of 1940s international espionage, and also frequently incorporates such themes as Pirates, The Circus and music.

In addition to comics, Kindt hosts a large portfolio of illustration work and teaches a class on drawing comics at Star Clipper Comics in University City, MO.

Kindt's collaboration with Brett Warnock on the design for Lost Girls (by Alan Moore and Melinda Gebbie) was nominated for the Eisner Award in publication design in 2007.

It was announced in June 2010 that his The Secret History of the Giant Man had been optioned by Warner Bros for a film to be written by Dustin Lance Black.

• 2002:
• Nominated for "Best Graphic Album of Original Work" Harvey Award, for Pistolwhip
• Nominated for "Best New Talent" Harvey Award

• 2005: Nominated for "Talent Deserving Wider Recognition" Eisner Award, for Pistolwhip and 2 Sisters
• 2007: Nominated for "Best Publication Design" Eisner Award, for Lost Girls
• 2008: Nominated for "Best Graphic Album: Reprint" Eisner Award, for Super Spy