Drogin was born prematurely and weighed only 3 pounds, 7 ounces. She and her younger brother were raised in Spring Valley, New York. She attended Brandeis University, where she met her husband. She later attended Boston University School of Law, and earned her law degree from New York University. Drogin passed the New York State Bar Exam in 1991, and was sworn in at the same time as John F. Kennedy, Jr. Although she enjoyed law school, she realized quickly that she did not enjoy practicing law. After the birth of her first child in 1992, Drogin became a stay-at-home mother and eventually decided to try writing. It took seven years, during which time she completed ten books, but in 1998 she finally sold a novel to Harlequin for their Temptation Line. In 2002 Drogin's first single-title novel, The Bachelor, was selected a book pick for Kelly Ripa's "Reading With Ripa" book club. This big break allowed the book to rise as high as number four on the New York Times Bestseller List (tied with a book by fellow romance novelist Nora Roberts).

Drogin promotes awareness for Susan G. Komen for the Cure, the Humane Society, and the American Heart Association. She is a huge fan of the New York Mets and the Boston Red Sox.

Simply series

Simply Scandalous(2000) Simply Sinful(2000) Simply Sensual(2001) Body Heat(2001) Simply Sexy(2002)

Hot zone series

Hot Stuff(2004) Hot Number(2005) Hot Item(2006) Hot Property(June 24, 2008) (last of the "Hot Zone" Series)

Stand alone novels

Brazen (1999) Secret Fantasy (2001) Erotic Invitation (2001) Seduce Me (2008) (reprint of Erotic Invitation)

Corwin curse series

Lucky Charm (October 2008) Lucky Streak (June 2009) Lucky Break (September 2009)

Costas sister series

• Under the Boardwalk (2004)Summer Lovin' (2005)

Ty & Hunter series

• Cross My Heart (2006) Sealed With A Kiss (2007)

Chandler brothers series

The Bachelor (2002)The Playboy (2003) The Heartbreaker (2003)

Written As Karen Drogin

• Perfect Partners (1999)
• The Right Choice (2000)
• Solitary Man (2000)

Omnibus

• Naughty or Nice? (2001) (with Sherrilyn Kenyon, Patricia Ryan and Kathryn Smith)
• Invitations to Seduction (2003) (with Janelle Denison and Vicki Lewis Thompson)
• Stroke of Midnight (2004) (with Jacquie D'Alessandro, Janelle Denison)
• Skin Tight / Hot Number (2005) (with Susan Andersen)
• Undone: Going All the Way / Her Secret Thrill / Good Time Girl (2005) (with Donna Kauffman and Candace Schuler)
• Santa, Baby (2006) (with Jennifer Crusie, Lori Foster)