Macy graduated from Wellesley College in 1950 and received her Phd in 1978 from the State University of New York, Syracuse. She is an international spokesperson for peace, justice, and environmentalism, most renowned for her book Coming Back to Life: Practices to Reconnect Our Lives, Our World and the Great Turning initiative, which deals with the transformation from, as she terms it, an industrial growth society to what she considers to be a more sustainable civilization. She has created a theoretical framework for personal and social change, and a workshop methodology for its application. Her work addresses psychological and spiritual issues, Buddhist thought, and contemporary science.

Macy travels giving lectures, workshops, and trainings internationally. Widowed in January 2009, she lives in Berkeley, California, near her children and grandchildren. She serves as adjunct professor to three graduate schools in the San Francisco Bay Area: the Starr King School for the Ministry, the University of Creation Spirituality, and the California Institute of Integral Studies.