Thirteen-year-old Fuller committed to the Christian faith in April 1916 at a Chapman-Alexander (John Wilbur Chapman and Charles Alexander) revival meeting in North Carolina and was baptized in the First Baptist Church of New York City by Dr. I. M. Haldeman. The title of the sermon he heard that day was "What Wilt Thou Say When He Shall Punish Thee."

Dr. Fuller served as a United States Navy chaplain in World War II, then for the next 45 years he was a pastor in a civilian capacity. He served as the editor of the General Association of Regular Baptists' "Baptist Bulletin" for 50 years.

He was the founder of Cornerstone University in Grand Rapids (at the time named Baptist Bible Institute), serving as president from 1941 to 1944. and the founder and president of the "Which Bible?" Society.

He helped establish the Children's Bible Hour in 1942, and was the chairman of this large ministry [it is on nearly 600 radio stations] for 33 years. He also cared deeply for world missions and was for 52 years on the board of the Association of Baptists for World Evangelism.

A great love for the Bible was one of the distinguishing features of Fuller’s life and ministry. By the time he retired from 40 years as pastor of the Wealthy Street Baptist Church in 1974, he had read the Bible through 75 times.

Fuller dedicated much of his life to the defense of the Byzantine text-type as embodied in the Textus Receptus and, largely, the King James Version.

In February 1988, Fuller died at Blodgett Memorial Medical Center in Grand Rapids, Michigan.

Fuller’s three volumes on the subject of texts and versions contain the full or summarized works of many older authorities on the textual issue. The most notable influence being Benjamin G. Wilkinson. Others include John Burgon, Herman C. Hoskier, Philip Mauro, Joseph Philpot, Samuel Zwemer, and George Sayles Bishop, as well as the works of a number of contemporary writers, including Edward Hills, Terence Brown, and Wilbur Pickering.

The Baptist researcher Doug Kutilek in his article The Unlearned Men has traced some of what Fuller wrote in his book, Which Bible? to what Seventh-day Adventist scholar Benjamin G. Wilkinson wrote in his own book concerning the textual debate, Our Authorized Bible Vindicated. David was also known to deliberately conceal Wilkinson's Adventist beliefs, which in turn, helped to spread his cause in defending both the King James Bible and the Textus Receptus.

Books

• Which Bible? Grand Rapids: Grand Rapids International Publications, 1970. 3rd ed. 1972. ISBN 0-944355-24-2
• True or False? The Westcott-Hort Textual Theory Examined Grand Rapids: Grand Rapids International Publications, 1973. ISBN 0-944355-12-9
• Counterfeit or Genuine? Grand Rapids: Grand Rapids International Publications, 1978. ISBN 0-8254-2615-4