Huston is one of the very few authors to have the movie rights to one of his books (Caught Stealing) sold before it was even bought by a publisher. A movie based on Caught Stealing was under development by Crossroads Films. However, recent statements by Huston have suggested Crossroads Films's option on the book has expired.

Caught Stealing along with Six Bad Things and Huston's fourth novel, A Dangerous Man, follow the lovable anti-hero, Henry Thompson, as he works his way through mistaken identity, his past, and a new life for himself.

In 2005 with the release of Already Dead, Huston put a new spin on vampires with the beginning of a new saga he refers to as the "Joe Pitt Casebooks". A departure from his first two books, Already Dead focuses on Vampire clans which control the underworld in and around New York City, as well as protagonist Joe Pitt, a vampire who does odd jobs for different clans, while retaining the gritty noir style Huston is known for. The series contains Already Dead, No Dominion, Half the Blood of Brooklyn, Every Last Drop, and the final book My Dead Body. The series is now complete.

In 2006 Huston joined the list of print authors who have decided to try writing American comic books. In April 2006, Marvel Comics launched Huston's reboot of the Marvel character Moon Knight. The work is an ongoing series, for which Huston wrote the first 12 monthly issues. His run concluded in December 2007, but he continues to aid in the plotting. He also wrote the second Ultimates annual in August 2006. It was recently announced that Huston will reboot the character Deathlok in a mini-series with artist Lan Medina.

Huston's first stand-alone novel, The Shotgun Rule, was published in August 2007. According to the author, "The Shotgun Rule is the story of a group of teenage delinquents that break into the wrong house and steal the wrong thing in a California suburb in the ’80s." This book also marks Huston's first book in third person instead of his trademark first person view.

Also, Huston has had two short stories featuring the same female protagonists published in two anthologies focusing on different aspects of noir. The first was published in Expletive Deleted on November 20, 2007, while the second was published in A Hell of a Woman: An Anthology of Female Noir on December 3, 2007.

Huston's latest book, The Mystic Arts of Erasing All Signs of Death was released in early 2009 and introduces a new character, Webster Fillmore Goodhue, that will be further developed in upcoming books.

As of April 27, 2009, Huston had written two more books planned for release in late 2010.

Huston will also be the writer for a new Wolverine series, The Best There Is with artist Juan Jose Ryp.

Hank Thompson trilogy

• Caught Stealing (2004)
• Six Bad Things (2005)
• A Dangerous Man (2006)

Joe Pitt Casebooks

• Already Dead (December 27, 2005)
• No Dominion (December 26, 2006)
• Half the Blood of Brooklyn (December 26, 2007)
• Every Last Drop (September 30, 2008)
• My Dead Body (October 13, 2009)

Stand-alone novels

• The Shotgun Rule (2007)
• The Mystic Arts of Erasing All Signs of Death (2009)
• a novel (2010)

Comic books

• Moon Knight vol. 5 #1-13 (2006-2007 (writer)), #14-19 (2007-July 2008 (plot help))
• Ultimates 2 Annual #2
• Punisher Max Hot Rods of Death One-Shot
• Legion of Monsters: Man-Thing (with Klaus Janson, one-shot, Marvel Comics, May 2007)
• The Best There Is (with Juan Jose Ryp, Marvel Comics, 2010, forthcoming)